High resolution ESI mass spectrometer for high throughput accurate mass determination

七个研究小组，其中涉及现代合成的不同领域的合成方法的发展，参与这一应用。他们的研究导致了大量的样本进行分析。质量的短期测定对于方法的控制和优化是绝对必要的。此外，新化合物的精确质量的测定同时需要在高级别期刊上发表。所要求的仪器将安装在有机化学研究所质谱分析中心，用于分析和表征新化合物。具有电喷雾电离（ESI）和电子电离（EI）的仪器目前可用于测定准确的质量。1台ESI质谱仪自2020年2月起出现故障，因成本原因未修复。ESI精确质量测量目前在两台仪器上进行。其中一个必须从研究所的资金中购买，作为有缺陷的仪器作为廉价的二手仪器的紧急替代品。然而，这两种仪器都已经使用了12年以上，因此需要一种新的高性能仪器用于高通量，以科普来自所涉研究小组的大量样品。此外，另一个较旧的LC-MS系统在2021年的缺陷使得这种更换变得迫切，因为LC-MS目前除了在其他大量使用的ESI仪器上进行常规分析外，还必须进行。

Seven research groups, which deal with the development of synthetic methods in different areas of modern synthesis, participate in this application. Their studies lead to a large number of samples to be analyzed. The short-term determination of the mass is absolutely essential for the control and optimization of methods. Furthermore, the determination of the accurate masses of new compounds is meanwhile required for publication in high-ranking journals. The requested instrument will be installed in the central department for mass spectrometry in the Organic Chemistry Institute for the analysis and characterization of novel compounds. Instruments with electrospray ionization (ESI) and electron ionization (EI) are currently available for determination of accurate masses. One ESI mass spectrometer is out of order since 2/2020 and has not been repaired for reasons of cost. ESI accurate mass measurements are currently conducted on two instruments. One of them had to be procured from institute funds as an urgent replacement for the defective instrument as an inexpensive used instrument. Both instruments, however, are already more than 12 years old, so that a new, high-performance instrument is required for use in high throughput in order to cope with the high number of samples from the involved research groups. Further, the defect of another older LC-MS system in 2021 makes this replacement urgent, since LC-MS currently has to be carried out in addition to the routine analysis on the other heavily used ESI instruments.