Metagenomic Analysis of Oral Microbiota from Normal Subjects and Patients with Periodontal Disease

对牙周健康受试者和牙周炎患者牙菌斑微生物区系进行了元基因组分析。对这七个DNA样本的深度测序总共检测到996个物种，并揭示了牙菌斑中比之前已知的更多的微生物多样性。将这些样本的功能结合谱与其他环境元基因组数据集(如人类肠道微生物区系)进行了比较。在斑块样本中观察到“防御机制”和“碳水化合物的运输和代谢”两类基因的丰富。

A metagenomic analysis of dental plaque microbiota obtained from periodontal healthy subjects and periodontitis patients was performed. The deep sequencing of the seven DNA samples detected total of 996 species and revealed substantially greater microbial diversity in the dental plaque than previously known. The functional binning profiles of these samples were compared with other environmental metagenome datasets such as human gut microbiota. Enrichments of genes in the categories of 'Defense mechanism' and 'carbon hydrate transport and metabolism' were observed in plaque samples.