Mechanisms of the development of neuronal cell community in the central nervous system

我们一直在寻找调节发育中小鼠大脑皮层脑室下区（SVZ）/多极细胞聚集区（MAZ）神经元产生模式的分子。作为功能测定和比较基因组分析的结果，我们确定了一些重要的候选人，可以改变SVZ中增殖神经元祖细胞的数量。我们还发现了多种可能影响MAZ中多极细胞行为的受体和配体。最后，我们表明，多极细胞在MAZ的行为是通过PI（3，4）P2-Lamelliodin-Ena/VASP-肌动蛋白系统控制。

We have searched for molecules that regulate the patterns of neuronal production in the subventricular zone (SVZ)/multipolar cell accumulation zone (MAZ) of the developing mouse cerebral cortex. As the results of functional assays and comparative genomic analyses, we identified some important candidates that could change the number of proliferative neuronal progenitors in the SVZ. We also have found multiple receptors and ligands that could affect the behavior of multipolar cells in the MAZ. Finally, we show that the behavior of the multipolar cells in the MAZ is controlled through the PI(3,4)P2-Lamellipodin-Ena/VASP-actin system.