Risk evaluation of environmental carcinogenesis

我们报道N-ERC/Mesothelin可能是间皮瘤有用的血液肿瘤标记物。为了调查这种肿瘤标志物是否对大规模检查中的早期诊断有用，我们在日本开始了一项针对有石棉暴露风险的建筑工人的大规模试点研究筛查。结论：血液肿瘤标记物有助于集体检查的早期诊断，并有可能延长患者的生存期。结果表明，给予多壁碳纳米管、人造矿物纤维或温石棉的大鼠，其血浆N-ERC水平在腹腔注射后10周仍持续升高。注射比其他非致癌物质。

We reported N-ERC/mesothelin might be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for an early diagnosis in a mass examination, we started a large-scale pilot research screening in Japan for construction workers with the risk of asbestos exposure. In conclusion, it is indicated that the blood tumor marker is useful for an early diagnosis in a mass examination and may lead to the prolongation of their survival. We havedemonstrated that plasma N-ERC levels of rats administered multi-wall carbon nanotube, man-made mineral fibers or chrysotile were continuously higher even at 10 weeks after intraperitoneal (i.p.) injection than the other non-carcinogenic materials.