Regulatory mechanisms in skeletal muscle lipid hydrolysis

人类骨骼肌对肌内甘油三酯(脂肪)利用的调节在很大程度上是未知的。我们的论点是，特殊的蛋白质酶，激素敏感脂肪酶(HSL)，在肌肉内三酰甘油的利用中起着基础性的作用，并受肌肉内关键代谢物水平和循环激素浓度的调节。我们还提出，HSL激活后的控制点对甘油三酯的水解很重要。我们建议的项目将研究这些因素，并将加强我们对肌肉脂肪使用的调节的理解，从而导致潜在的代谢策略(营养、药物)，以增强骨骼肌在休息和运动期间的功能。

The regulation of intramuscular triglyceride (fat) utilisation by human skeletal muscle is largely unknown. Our contention is that the specialized protein enzyme, hormone sensitive lipase (HSL), has a fundamental role in intramuscular triacylglycerol utilisation and is regulated by both intramuscular levels of key metabolites and circulating hormone concentrations. We also propose control points subsequent to HSL activation are important for triglyceride hydrolysis. Our proposed project examines these factors and will enhance our understanding of the regulation of muscle fat use, thereby leading to potential metabolic strategies (nutritional, pharmacological) that enhance skeletal muscle function at rest and during exercise.