600 MHz-spectrometer with probes and autosampler

为了加强莱比锡大学有机化学研究所核磁共振核心设施的性能和方法谱，需要一台带有高灵敏度氮气冷却探头的600兆赫核磁共振仪器。收购新的核磁共振仪器将满足目前对核磁共振服务的需求，由于莱比锡大学化学和矿物学系、Tanja Gulder教授(有机化学研究所)和Jens Meeller教授(药物开发研究所)的新任命，核磁共振服务的需求已大幅增加。在这些任命的同时，在参与机构内部和之间建立了新的研究活动，因此，对核磁共振服务和测量的需求普遍增加。此外，需要为高通量核磁共振实验提供新的核磁共振服务，例如通过定向进化开发酶作为生物催化剂，以及药物活性试剂。在这两个研究领域，通过小分子-蛋白质相互作用研究结构-活性关系是必要的，需要采购一台拥有500个位置的自动取样器。这样，就效率而言，将达到安装高灵敏度探头的最大容量。

A 600 MHz NMR instrument with a highly sensitive nitrogen-cooled probe is requested to enhance the performance and the methodological spectrum of the NMR Core Facility at the Institute of Organic Chemistry of Leipzig University. The acquisition of the new NMR instrument will meet the current requirements for NMR service, which have been significantly increased due to the new appointments of the Faculty of Chemistry and Mineralogy at Leipzig University, Prof. Tanja Gulder (Institute for Organic Chemistry) and Prof. Jens Meiler (Institute for Drug Development). These appointments have been accompanied by establishing new research activities at and in between the participating institutes and, consequently, by a general increase in the demand for NMR service and measurements. In addition, new NMR services for high-throughput NMR experiments in the context of e.g. the development of enzymes as biocatalysts by directed evolution, as well as of pharmaceutically active agents are needed. In both research areas, investigations on structure-activity relationships by small molecule-protein interactions are necessary, requiring the procurement of an autosampler with 500 positions. With this, the maximum capacity of the installation of a highly sensitive probe in terms of efficiency will be achieved.