Analysis of neuro oncogenesis by genetically different susceptible strains of rats.

本研究主要目的是探讨乙基亚硝基脲（ENU）对不同品系大鼠神经肿瘤的诱导作用。新生大鼠给药后，几乎100%的脑皮质肿瘤、三叉神经肿瘤均可诱导发生。类似的药物，甲基亚硝基脲（MNU）也可以诱导神经系统肿瘤，也可以诱导肾脏和乳腺肿瘤。肾脏和乳腺肿瘤的发生有其特殊性，其中肾脏肿瘤似乎受隐性性状的调控，而乳腺肿瘤则受孟德尔定律的调控。这项研究已经扩展到更详细地分析遗传背景。

This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.The study has been extended to analyze the genetical background in more details.