Bio-metrology and modelling of a complex system: the malaria parasite

复杂系统的生物计量学和建模：疟疾寄生虫：该奖学金项目旨在开发一个跨学科的计划，以测量、建模和操纵复杂的细胞系统--人类疟疾寄生虫的性别分化。该项目将生命科学和物理科学与强大的成像技术相结合，寻求开发定量的生化、生物物理和建模技术，以一种以前无法实现的方式探测复杂的系统。它希望整合和关联细胞内动态过程的数千个测量结果，并使用这些数据集生成严格和复杂的数学模型，这些模型可以预测寄生虫转变为有性阶段的承诺驱动因素，为传播给蚊子做准备。这种整体方法希望带来新的生物技术和生物医学成果，包括抗击牲畜和人类疾病的新方法。

Bio-metrology and modelling of a complex system: the malaria parasite: This fellowship project aims to develop a cross-disciplinary program to measure, model and manipulate a complex cellular system — sexual differentiation of the human malaria parasite. Combining life and physical sciences with powerful imaging techniques, the project seeks to develop quantitative biochemical, biophysical and modelling techniques to probe a complex system in a way previously not possible. It expects to integrate and correlate thousands of measurements of the dynamic processes inside cells and use these datasets to generate rigorous and sophisticated mathematical models that can predict drivers of commitment for transformation of the parasite to a sexual phase in preparation for transmission to mosquitoes. This holistic approach hopes to deliver new biotechnology and biomedical outcomes, including new ways to combat disease in livestock and humans.