Analysis of the Fetal Functional Maturity

在高危妊娠的处理中，胎儿功能成熟度的评估是最重要的。最近，所谓的“胎儿行为”被认为是最可靠的信息。本研究对胎儿运动、胎儿心率、胎儿对声音刺激的反应、胎儿呼吸运动、胎儿眼动与快速眼动和非快速眼动睡眠状态的关系等胎儿行为进行了定量分析。并分析了药物对胎儿神经系统的影响。在复杂的情况下，如EPH和IUGR，胎儿神经功能明显受到抑制。(1)胎动次数和力度受到抑制，(2)胎动时加速次数也受到抑制，(3)加速倾斜度降低，但加速度高度保持不变，(4)复杂情况下胎儿对声音刺激的反应受到抑制，(5)胎儿呼吸运动明显减弱，(6)胎儿眼动也受到抑制。关于药物对胎儿的影响，即使在正常血清浓度下，氯丙嗪或氟哌啶醇也能准确地降低胎儿运动和FHR加速。另一方面，在正常血清药物浓度下，抗惊厥药（苯妥英和苯巴比妥）对胎儿无抑制作用。

In the management of the high-risk pregnancy, the evaluation of the fetal functional maturity is most important. Recently, so called "fetal behavior" has been regarded as the most reliable information.In this study, the quantitative analysis of fetal behavior concerning fetal movements, fetal heart rate, fetal reaction to sound stimulation, fetal breathing movement, fetal eye movement in relation to REM and non-REM sleep state were carried out. And effects of drug on the fetal nervous system were also analyzed.In the complicated cases, such as EPH and IUGR, fetal nervous functions were clearly suppressed. (1) The number and strength of the fetal movement were suppressed, (2) the number of acceleration at fetal movement were also suppressed, (3) the inclination of acceleration reduced, however the the height of acceleration remained unchanged, (4) the reaction to the sound stimulation was suppressed in the complicated cases, (5) the fetal breathing movement diminished clearly, (6) The fetal eye movement was also suppressed. Concerning the effect of drug to the fetus, fetal movement and FHR accerelation were accurately diminished by the administration of chlorpromazine or haloperidol even in normal serum concentration. On the other hand, anticonvulsant (Phenytoin and Phenobarbital) showed no depressive effect on the fetus under the normal serum drug concentration.