Synthesis and Design of Structures of Biologically Active Compounds

本研究项目的目的如下：（1）开发生物活性化合物的有效合成方法，（2）鉴定化合物显示生物活性所必需的分子结构，（3）在分子水平上阐明动物和植物的生命，以及（4）设计对人类生命有用的新生物活性化合物。研究小组由16名教授组成，研究项目分为四个：（1）研究生物活性肽的合成方法和负责其生物活性的结构，（2）研究糖和大环内酯的合成方法和负责其生物活性的结构，（3）除了开发抗癌药物外，还开发用于治疗循环器官和中枢神经系统疾病的药物，以及（4）通过物理化学方法研究负责生物活性的结构。我们已经成功地进行了所有这些项目，我们的项目最终对生物活性化合物的合成和结构设计的未来发展有很大的希望。

The purpose of this research project is as follows : (1) exploitation of efficient synthetic methods for biologically active compounds, (2) identification of the molecular structures which are essential to exhibit biological activities of the compounds, (3) clarification of life of animals and plants on molecular levels, and (4) design of new biologically active compounds useful for human life. The research groups have consisted of 16 professors and the research projects have been divided into four : (1) investigations of biologically active peptides on their synthetic methods and on the structures responsible for their biological activities, (2) investigations of sugars and macrolides on their synthetic methods and on the structures responsible for their biological activities, (3) development of drugs useful for the treatment of diseases on circulatory organs and central nervous system in addition to development of anticancer drugs, and (4) investigations on structures responsible for biological activities by the physicochemical methods. We have successfully pursued all of these projects, and our projects ended to have a great promise of the future development on the syntheses and design of structures of biologically active compounds.