Research project on the varient modification of thermosensitivity in the

本研究项目在细胞和身体水平上对温度敏感性的变异修饰进行了研究，其特点是由8名环境生理学家、3名辐射生物学家、2名分子生物学家和3名神经生理学家组成的跨学科研究领域。1.从温度调节、发热、出汗、免疫学、内分泌、细胞和分子生物学水平分析了与细胞功能的敏感性和耐热性有关的基本问题。2.神经降压素、蛙皮蛋白等神经肽的温度调节点及其调节。神经肽Y.降钙素基因相关肽(CGRP)不仅与上述神经肽有关，还与辐射和分子生物学家报道的各种细胞因子如IL-1α、热休克蛋白(HSP70，47)、栎素(HSP诱导抑制物)和内毒素-热原等有关。

The present Research project on the varient modification of thermosensitivity in the cellular and bodily level is characterized by the interdisciplinary research fields that are composed of 8 Environmental physiologists, 3 Radiation Biologist, 2 Molecular Biologists and 3 Neuro-physiologists.1.The essential problems concerned with themosenstivity as well as with thermo-tolerance of cellular function were analyized from the view points of themoregulatory, febrile, sweating, immunological, endocrinological, cellular, and molecular biological levels.2.The thermoregulatory set-point and its modication of the varient neuro-peptides such like neurotensin, bombesin, neuropeptide Y.calcitonin gene-related peptide (CGRP) were reported by the present Environmental physiologists.3.Thermosensitivity and thermotolerance are modified not only by the above-mentioned neuropeptides but also the variant cytokines such like IL-1alpha beta, Heat Shock Proteins (HSP70,47), Quercetin(Suppressor of HSP induction) and LPS-pyrogen which were reported by radiation and molecular Biologists.