Analysing system for homeostatic control during exercise.

在运动过程中，维持体内平衡的调节系统，如心血管和呼吸系统，协调工作以完成有效的肌肉活动。有两种途径可以实现这种组织良好的自我平衡调节的整合。一种是负反馈系统，它与来自肌肉或关节的神经元或体液信号一起起作用，涉及肢体运动或代谢。另一种是由高级运动中枢向自主神经系统（中枢指令）发出的信号触发的前馈系统。特别是这种前馈系统的大脑机制是完全未知的。其中一个原因是没有合适的动物模型来研究这个问题。本研究的目的是建立一个测量自主运动大鼠自主神经功能的系统。该实验是在Wister雄性大鼠身上进行的。我们使用了老鼠跑的旋转轮子。给大鼠植入两个遥测仪，一个用于测量血压和心率，另一个用于测量肌电图。轮子的转动（老鼠的运动）和遥测仪的输出被输入计算机。编制了分析大鼠运动与血压、心率变化的时间关系的程序。大鼠真正掌握了在轮子上跑步，并且观察到血压随跑步运动同时变化。该系统将成为分析运动过程中控制体内平衡的神经元机制的有力工具。

During exercise regulatory systems for maintaining homeostasis, such as cardiovascular and respiratory ones, work in harmony to fulfilll the efficient musculare activities. There are two routs for accomplishing this well-organized integrations of homeostatic regulation. One is negative feedback system which is brought into action with the neuronal or humoral signls from the muscles or joints concerning the movement of the limb or metabolism. The other is the feed foreward system which is triggered by the signals from the higher motor center to the autonomic nervous systems (cemtral command). The brain mechanisms especially for this feed foreward system is totally unknown. One of the reason is there is no proper animal models to study this question. The purpose of this study is to develop a system for measuring autonomic functions from the spontaneously exercising rats. The experiment were made in Wister male rats. We used rotating wheels in which a rat ran. The rat was implanted with two telemeters, one for measuring blood pressure and heart rate and the other for measuring EMG.The rotation of the wheel (movement of the rat) and the output from the telemeters were fed into the computer. A program for analyzing temporal relations between rat's movement and the change in blood pressure or heart rate was made. Rats ealily mastered running in the wheel, and it was ovserved a simultaneous blood pressure change with running movement. The present system would become a very powerful tool for analyzing the neuronal mechanisms for controlling homeostasis during exercise.