A novel axis of cooperation between innate and adaptive immunity

该项目旨在了解免疫系统的两种分子成分补体和MHC如何合作保护宿主。此外，这两种分子介导树突状细胞和B细胞这两种主要免疫细胞类型之间的细胞间通讯，这是一种很少被研究的细胞间通讯形式。该项目将是多学科的，应用高端显微镜、生物化学、细胞生物学和免疫学技术。员工将接受尖端技术的培训。该项目将扩大基础免疫学和细胞-细胞合作的知识。它将为生物技术部门创造知识产权，以开发新的商业产品，这些产品可能会改善人类和具有经济重要性的动物的健康。

The project aims to understand how two molecular components of the immune system, Complement and MHC, cooperate to protect the host. Further, these two molecules mediate trogocytosis, a little-studied form of intercellular communication, between two major immune cell types: dendritic cells and B cells. The project will be multidisciplinary, applying high-end microscopy, biochemistry, cell biology and immunology techniques. Personnel will be trained in cutting-edge techniques. The project will expand knowledge on basic immunology and cell-cell cooperation. It will generate intellectual property for the biotechnology sector to develop new commercial products that might improve the health of humans and also animals of economic importance.