Development and Application of the Conceptionally New Catalytic Asymmetric Aldol Reaction

开发一种催化的不对称Aldol反应是当今的一项艰巨的挑战。手性Lewis酸催化剂已有报道。然而，这种方法在通用性和适用性方面仍存在许多问题。因此，我们利用手性钯催化剂研究了一种新的合成方法。我们发现，即使在少量水存在的情况下，Aldol反应也可以高产率地进行，并通过钯的烯醇酸进行ee反应。此外，我们对催化剂的结构和反应机理进行了研究和确定。

Developing a catalytic asymmetric aldol reaction is a formidal challenge nowadays. Chiral Lewis acid catalysts have been reported. However, this approach still has many problems in versatility and applicability. Thus, we investigated novel approach by using the chiral palladium catalyst. We have found that the aldol reaction proceeds in high yield and ee via the palladium enolate even in the presence of small amount of water. Furthermore, we have investigated and determined the catalyst structure and the reaction mechanism.