Combating Antimicrobial Resistance with Bismuth, Gallium and Indium

该研究项目的重点是设计，开发和应用新的铋，镓和铟化合物作为抗菌剂。这些金属在体内充当铁模拟物，并且可以发挥抗微生物活性，同时在人体中显示出低全身毒性。该项目旨在利用这一点，以及微生物无法轻易对金属产生耐药性，以对抗现代药物迅速失效的细菌，正如世界卫生组织和美国疾病控制中心的关键和优先病原体清单所强调的那样。预期的结果是，疗效将通过合成和结构化学的进步，发现作用模式，并创造抗感染涂层和水凝胶来驱动。

This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapidly becoming ineffective, as highlighted in the WHO and US Centre for Disease Control list of critical and priority pathogens. The intended outcome is that efficacy will be driven through advances in synthetic and structural chemistry, discovering the mode of action, and creating anti-infective coatings and hydrogels.