Relationship of the Intake of Selenium and Antioxidant Vitamins to Serum Lipid peroxide

通过高质量的营养调查和血液检查，对300名40 ~ 59岁表面健康的男女进行了硒和抗氧化维生素的摄入与血清脂质过氧化值（TBA值）的关系进行了研究。主要结果如下：1。血清脂质过氧化（LPO）在男性和老年受试者中较高。年龄增长趋势与其他因素无关。维生素C的摄入密度（每1000千卡能量摄入的摄入量）与血清LPO呈独立负相关。维生素C可能抑制人体脂质过氧化。血清α -生育酚浓度与血清lpo无关。维生素A摄入量与血清LPO无负相关。血清维生素A浓度与LPO呈正相关，这可能与脂肪肝引起的血清维生素A升高相混淆。硒摄入量与血清LPO无负相关。由于本研究对硒摄入量的估计并不充分，因此有必要建立硒摄入量表或测定血硒浓度。血清γ - gtp与血清LPO呈显著正相关，与酒精摄入或体重无关。LPO的产生会通过肝细胞损伤如肝脏炎症而增加。这些发现将有助于更好地评估氧化应激在疾病预防中的作用，并建立抗氧化剂的使用方法。

The relationship of the intake of selenium and antioxidant vitamins to serum lipid peroxide (TBA value) was investigated using a high-quality nutritional survey and blood examination among 300 apparently healthy men and women aged 40-59 years. The main results were as follows :1. Serum lipid peroxide (LPO) was higher in men and in older subjects. The increasing tendency by age was independent from other factors.2. The intake density (intake per 1000 kcal energy intake) of vitamin C was independently and inversely related to serum LPO.Vitamin C was likely to inhibit lipid peroxidation in human body.3. Serum alpha-tocopherol concentration was not related to serum LPO.4. Vitamin A intake was not inversely related to serum LPO.Serum vitamin A concentration was positively related to serum LPO, which was likely to be confounded by serum vitamin A increase through fatty liver.5. Selenium intake was not inversely related to serum LPO.Because the estimation of selenium intake was not sufficient in this study, The establishment of selenium consumption table or the determination of blood selenium concentration would be necessary.6. Serum gamma-GTP was strongly and positively related to serum LPO, independently from alcohol intake or body mass. The production of LPO would increase through liver cell damage such as inflammation in liver.These findings would contribute to the better assessment of oxidative stress in disease prevention and to establishing methods for the usage of antioxidants.