DEVELOPMENT AND CLINICAL APPLICATION OF IMPLANTABLE WEARABLE ARTIFICIAL ENDOCRINE PANCREAS WITH A TELEMETRY GLUCOSE MONITORING SYSTEM

为了对糖尿病患者的血糖浓度进行连续监测，研制了一种针式血糖传感器遥测血糖监测系统。该系统包括将针状葡萄糖传感器中产生的电流信号转换为高频音频信号的传感器发射器和从接收到的音频信号连续计算葡萄糖浓度的接收器。发射器，装有一个电流-电压转换放大器，一个电压-频率转换器和一个电池。接收器将音频信号解调为电压，由该电压计算出的葡萄糖浓度连续显示在LED显示屏中。超过预设阈值的高血糖或低血糖可通过声音发出警报。接收机由甚高频振荡器、调制器、电滤波器、频率电压变换器、报警电路和电池组成。接收器在发射器20米范围内捕获传感器信号。遥测系统监测记录的噪声范围小于可穿戴式人工内分泌胰腺——有线遥测系统。正常动物连续血糖监测显示，每只动物同时测得的皮下组织葡萄糖浓度与血浆葡萄糖浓度存在显著相关性。这些数据表明并提示遥测血糖监测系统在糖尿病患者血糖控制中的有效性。

For continuous monitoring glucose concentration in ambulant diabetic patients, a telemetry glucose monitoring system with a needle-type glucose sensor has been developed. The system consists of a sensor transmitter that converts current signals generated in a needle-type glucose sensor to high-frequency audio-signals and receiver that continuously calculates glucose concentrations from the received audio signals. The transmitter, packed with a current-voltage-converting amplifier, a voltage-frequency converter, and a battery. The receiver demodulates the audiofrequency signal to a voltage and the glucose concentration calculated from the voltage is continuously displayed in the LED display. Hyperglycemia or hypoglycemia beyond the prefixed threshold is alarmed by sound. The receiver is composed of a VHF oscillator, a frequency modulator, electric filters, a frequency-voltage converter, and an alarm circuit and batteries. The receiver catches the sensor signal within 20 m of the transmitter.The noise range of a monitoring record with the telemetry system was smaller than that with a wire-connected telemetry system, the wearable artificial endocrine pancreas.Continuous glucose monitoring of normal animal subjects revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each animal.These data indicate and suggest the usefulness of le telemetry glucose monitoring system in glycemic control of diabetic individuals.