Maternal immune system which cotribute to the maintenance of pregnancy in the decidua

已经证明，妊娠诱导细胞因子应答的免疫调节远离Th 1范式并朝向Th 2范式。在这项研究中，我们证明，Th 1细胞的百分比是最低的蜕膜在早期妊娠和最高的子宫内膜增殖期，其次是子宫内膜分泌期。另一方面，Th 2细胞的百分比是最高的蜕膜在妊娠早期和最低的子宫内膜在增殖期。我们进一步证明，不仅Th 2细胞，而且Tc 2细胞在早孕蜕膜中增加。这些结果表明，在母体系统中的蜕膜的Th 2-和Tc 2-型细胞的意义，大概是通过其生产的细胞因子，这可能有助于维持妊娠。进一步探讨异常妊娠状态子痫前期患者Th 1/Th 2平衡的变化。结果发现正常妊娠中晚期外周血中Th 2细胞占优势，子痫前期患者外周血中Th 1细胞占优势。我们证明了单核细胞产生的IL-12不仅在正常妊娠中而且在先兆子痫中调节Th 1/Th 2平衡。提示Th 2型免疫优势状态对妊娠的维持起重要作用，这种微妙的平衡失调可能导致异常妊娠，即反复流产和先兆子痫。

It has been demonstrated that pregnancy induces the immunomodulation of cytokine responses away from Th1 paradigm and towards the Th2 paradigm. In this study, we demonstrated that the percentage of Th1 cells was lowest the decidua in early pregnancy and highest in endometrium during the proliferative phase followed by endometrium in the secretory phase. On the other hand, the percentage of Th2 cells was highest in the decidua in early pregnancy and lowest in the endometrium during the proliferative phase. We further demonstrated that not only Th2 cells but also Tc2 cells increased in the early pregnancy decidua. These results indicate the significance of Th2- and Tc2- type cells of the decidua in the maternal system, presumably through their production of cytokines which may contribute to the maintenance of pregnancy. We further studied the Th1/Th2 balance in abnormal pregnancy state preeclampsia. We found that Th2 cells were predominated in peripheral blood in the second and third trimester of normal pregnancy, Th1 cells predominated in preeclamptic patients. And we demonstrated that IL-12 production by monocytes regulates Th1/Th2 balance not only in normal pregnancy but also in preeclampsia. Our data suggest that Th2 dominant immune state contribute the maintenance of pregnancy and the disturbance of this delicate balance might result in abnormal pregnancy ; ie recurrent abortion and preeclampsia.