Bidirectional approach with neurotrophic factors for the acceleration of neuro-regeneration.

使用神经营养因子的双向方法加速神经再生。

• 批准号: 20390411
• 负责人: SAITO Shigeru
• 金额: $ 7.49万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390411/
• 关键词: 疼痛管理学; 再生医学; 栄養因子; 痙痛管理学

For the better recovery of damaged neurons, cellular environment seems to be crucial. In the present study, the authors assessed effects of neurotrophic factors in various settings. As the results, it was revealed that normo-glycemia is the best condition for the neuro-regeneration. Newly developed drug delivery system was identified as effective for gradual release of nerve activity controlling drugs.

为了更好地恢复受损的神经元，细胞环境似乎是至关重要的。在本研究中，作者评估了神经营养因子在各种环境中的作用。实验结果表明，正常光照是神经再生的最佳条件。新开发的药物输送系统被认为可有效地逐渐释放控制神经活动的药物。

项目成果

Thermal hyperalgeria via supraspinal mechanisms in mice lacking glutamate decarboxylase 65

缺乏谷氨酸脱羧酶的小鼠通过脊髓上机制引起热过敏65

• 发表时间: 2009
• 期刊: J Pharmacol Exp Ther Vol.331(1)
• 作者: Kubo K;Nishikawa K;Hardy-Yamada M;Ishizeki J;Yanagawa Y;Saito S;Kubo K
• 通讯作者: Kubo K

Anatomic analysis of computed tomography images obtained during fluoroscopic computed tomography-guided percutaneous lumbar symnathectomy.

对荧光计算机断层扫描引导经皮腰椎交感神经切除术期间获得的计算机断层扫描图像进行解剖分析。

• 发表时间: 2008
• 期刊: Journal of Anesthesia 22
• 作者: Koizuka S;Saito S;Obata H;robe M;Koyama Y;Takahashi A.
• 通讯作者: Takahashi A.

Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postonerative pain model in rats.

鞘内注射米那普仑（一种血清素去甲肾上腺素再摄取抑制剂）在大鼠术后疼痛模型中的单胺依赖性、阿片类非依赖性抗过敏作用。

• 发表时间: 2010
• 期刊: J Pharmacol Exp Ther.
• 作者: 南野勝彦;名井陽;杉安謙仁朗;玉井宣行;橋本伸之;吉川秀樹;Obata H
• 通讯作者: Obata H

Monoamine-Dependent, Opioid-Independent Antihypersensitivity Effects of Intrathecally Administered Milnacipran, a Serotonin Noradrenaline Reuptake Inhibitor, in a Postoperative Pain Model in Rats

• DOI: 10.1124/jpet.110.168336
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Obata, Hideaki;Kimura, Masafumi;Saito, Shigeru
• 通讯作者: Saito, Shigeru

The radiobiological effectiveness of carbon-ion beams on growing neurons

• DOI: 10.1080/09553000903020032
• 发表时间: 2009-01-01
• 期刊: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
• 影响因子: 2.6
• 作者: Al-Jahdari，Wael S.;Suzuki，Yoshiyuki;Nakano，Takashi
• 通讯作者: Nakano，Takashi