Cytokine cross-talk in reproduction -the relationship between neuron system, immune system and endocrine system-

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In this study, we focus on the role of immune cells especially cytokine cross-talk in normal pregnancy and complicated pregnancy such as preterm delivery and preeclampsia. Results are as follows ; We clarified that type 2 cells are accumulated at implantation site by TARC and PGD2 dependent manner. We firstly reported that accumulation of type 2 cells decreased in the decidua basalis in recurrent spontaneous abortion with normal chromosomal content suggesting that type 2-dominant immune environment is important to maintain pregnancy.Assending inflammation, in which vaginitis is followed by cervicitis and chorioamnionitis is known cause of preterm labor. We investigated that whether high IL-8 levels in cervical mucus were valuable indications for treatment to prevent preterm labor. As a result, successful treatment for women with IL-8 elevations in cervical mucus decreased rates of premature birth.Preeclampsia is a most problematic complication during pregnancy. We showed that preeclampsia was associated with a Th1 predominant state, and may be considered a failure of tolerance. We also showed that serum granulysin levels in preeclapsia were well associated with mean blood pressure and Th1/Th2 ratios. These data suggest that serum granulysin is a useful and novel serum marker to evaluate the Th1/Th2 balance in preeclampsia.