A study of neural mechanisms of the sleep apnea (A possible approach from dentistry)

在麻醉的大鼠中，刺激运动皮质a区产生类似磨牙的下颌运动。然而，a区刺激产生的类似磨牙的下颌运动并没有引起呼吸暂停。脑干的臂旁区域引起了呼吸暂停。<2000-2001>麻醉大鼠的睡眠状态重现。使用脑电图（EEG）来评估睡眠状况。分析脑电功率谱，δ波随氟烷浓度的增加而增大。浓度为1.5%和2.0%时脑电图δ波的比例与睡眠时相同。<2001-2002>(1)激活桥蛋白蓝斑座（LC）可抑制三叉神经感觉运动功能。这一发现表明，LC的激活抑制了睡眠中类似磨牙的下颌运动。(2)在吸气过程中，三叉神经运动神经元的兴奋与吸气神经元的兴奋同步。这一发现提示了呼吸运动与三叉神经运动神经元兴奋之间的关系。

<1999-2000>In anesthetized rats, stimulation of the motor cortex A-area produced bruxism-like jaw movement. Bruxism-like jaw movement produced by A-area stimulation, however, did not induce the apnea. Parabrachial region in the brainstem induced the apnea.<2000-2001>The condition of sleep was reproduced in anesthetized rats. Electroencephalogram (EEG) was used to estimate the condition of sleep. When power spectrum of the EEG was analyzed, δ wave increased with he increase of concentration of halothane. The ratio of δ wave in the EEG under the concentration of 1.5 and 2.0 % was the same as compared with the ratio under the condition of sleep.<2001-2002>(1) Activation of the pontin locus coeruleus (LC) inhibited trigeminal sensorimotor function. This finding suggests that activation of the LC suppressed bruxism-like jaw movement during sleep.(2) During inhalation, excitation of trigeminal motoneurons synchronized with excitation of inspiratory neurons. This finding suggests the relationship between respiration movement and excitation of trigeminal motoneuron.