Creative functional conversion of food resources with poor utility into alternative medical foods

1. 花青素对餐后血糖水平的抑制作用。为了优化食物成分对餐后糖苷对糖尿病的预防作用，研究了多种富含authocyanins的植物对α-葡萄糖苷酶（AGH）的抑制作用。通过AGH体外抑制筛选，山川紫甘薯（YGM）具有较强的麦芽糖酶抑制作用，IC50值为0。26个毫克/毫升。麦芽糖提取物对SD大鼠单次口服麦芽糖后BGL也有明显的体内抑制作用。通过对YGM活性化合物的分离，发现酰基化花青素具有较强的抑制AGH（麦芽糖酶）活性。小麦胚芽水解产物中ACE抑制肽（IVY）的抑制机制。为了阐明小麦胚芽水解物中il - val - tyr （IVY）的抑制作用，本文对其在SHR患者体内****高血压作用进行了初步研究。静脉注射IVY （5mg/kg）后，显著降低（P< 0.05）。0.05) 8 min血压降低（ΔMBP=19）。2 mmHg)，并保持降低20分钟。通过使用大鼠和人的血浆。研究发现，IVY可通过血浆中氨基肽酶的作用代谢，形成一种具有降压作用的ACE抑制剂VY。由此可见，摄入常青藤或小麦胚芽水解物后，可通过常青藤和常青藤的联合抑制作用来调节血压。荞麦蛋白的潜在降压作用。研究了酒石酸BW潜在产生的ACE抑制剂，以及对ACE抑制负责的肽的特性。经胃蛋白酶、胰蛋白酶和凝乳胰蛋白酶依次消化后，ACE抑制活性显著升高(IC50；14 mg-protein /毫升)。芦丁对ACE无抑制作用。单次口服BW消化液4小时后，SHR血压降低约30 mmHg。从BW消化液中鉴定出11种肽为ACE抑制剂。本研究结果表明，BW蛋白在胃肠道消化过程后具有潜在的体内降压作用。少

1. Postprandial suppression of blood glucose level (BGL) by anthocyanins.In order to optimize the postprandial BGL by food components for the prophylaxis of diabetes, various plants rich in authocyanins were investigated with respect to α-glucosidase (AGH) inhibition. As a result of in vitro screening on AGH inhibition, Ipomoea batatas cv Yamagawamurasaki purple sweet potato (YGM) had a potent maltase inhibition with the IC50 value of 0. 26 mg/ml. The YGM extract also showed a potent in vivo supressive effect of BGL after single oral administration of maltose in SD rats. As a result of isolation of active compound in YGM, acylated anthocyanins were found to show a potent AGH (maltase) inhibitory activity.2. Depressor mechanism of ACE inhibitory peptide (IVY) derived from wheat germ hydrolysate.In order to elucidate the depressor effect of Ile-Val-Tyr (IVY) isolated from wheat germ hydrolysate, in vivo ****hypertensive effect of it in SHR was primarily investigated. After intravenous ad … More iminstration of IVY (5mg/kg), a significant (P<0. 05) blood pressure (BP) reduction was observed at 8 min (ΔMBP=19. 2 mmHg), and the reduction was held for 20 min. By using rat and human plasma. IVY was found to be metabolized by the action of aminopeptidases in plasma to form a subsequent ACE inhibitor with hypotensive effect, VY. Thus, the intake of IVY or wheat germ hydrolysate would serve in reguating BP by the combined depressor effect of IVY and VY, after absorption.3. latent antihypertensive effect of buckwheat (BW) protein.Latent production of ACE inhibitors from tartary BW, and the characterization of peptides responsible fcr ACE inhibition were investigated. Sequential digestion with pepsin, trypsin and chymotrypsin resulted in a significant increase of ACE inhibitory activity (IC50 ; 0. 14 mg-protein/ml). rutin did not show the ACE inhibition. About 30 mmHg of BP reduction in SHR was observed after single oral adiministration of BW digest at 4 h. From the BW digest, 11 peptides were identified as an ACE inhibitor. The findings in this study demonstrated that BW protein had a latent ability to exert an in vivo antihypertensive effect after the gastrointestinal digestion process. Less