COGNITIVE FUNCTION OF HEREDITARY HIGH RISK GROUP OF SCHIZOPHRENIA USING EVENT-RELATED POTENTIAL (ERP) AND FUNCTIONAL NEAR INFRARED SPECTROSCOPY (f-NIRS).

本研究采用事件相关电位（ERP）和功能近红外光谱（f-NIRS）检测精神分裂症遗传高危人群的认知功能。在事件相关电位（erp）研究中。对10名精神分裂症患者（8名男性，2名女性，30.0 +/- 6.1岁），10名性别匹配的兄弟姐妹（28.8 +/- 2.4岁）和10名性别年龄匹配的健康对照（29.0 +/- 3.2岁）进行erp检测。在一个听觉古怪的任务中记录erp。对分裂型人格问卷（SPQ）进行评估，并与SPQ进行相关性分析。兄弟姐妹组进行评分和ERP结果调查。(结果)1。与对照组相比，兄弟姐妹组和精神分裂症组的P300振幅均有所降低。P300潜伏期与对照组无差异。2. 精神分裂症患者与兄弟姐妹P300波幅呈显著正相关（r = 0.70, p<0.05）。3. 兄弟姐妹组Fz电极P300振幅与SPO_score呈负相关（r = -0.64, p<0.05）。3. 对P300的LORETA（低分辨率电磁断层扫描）分析显示，与对照组相比，精神分裂症患者及其兄弟姐妹的右额叶和双侧颞叶区的皮质电流密度分布有所减少。在精神分裂症患者和兄弟姐妹的比较中，尽管两组的皮层电流分布相似，但与兄弟姐妹相比，精神分裂症患者的左额极区电流密度降低。此外，在精神分裂症兄弟姐妹中进行了f-NIRS（功能性近红外光谱）检查，显示了f-NIRS在研究精神分裂症的生物学底物方面的潜在用途。

This research project examined cognitive function of hereditary high risk group of schizophrenia using event-related potential (ERP) and functional near infrared spectroscopy (f-NIRS). In the event-related potential (ERPs) study. ERPs were examined in 10 schizophrenic subjects (8 male, 2 female, 30.0 +/- 6.1 y.o.), 10 sex matched their siblings (28.8 +/- 2.4 y.o.) and sex-age matched 10 healthy controls (29.0 +/- 3.2 y.o.). ERPs were recorded during an auditory oddball task. Schizotypal Personality Questionnaire (SPQ) was evaluated and correlation of SPQ. Score and ERP results was investigated in sibling group. (Result) 1. Reduced P300 amplitude was found in sibling group as well as schizophrenic group compared to controls. P300 latency did not differ from controls. 2. Positive correlation of P300 amplitude between schizophrenics and their siblings at Pz electrode was found (r = 0.70, p<0.05). 3. Negative correlation between P300 amplitude at Fz electrode and SPO_score was found in sibling group (r = -0.64, p<0.05). 3. LORETA (Low Resolution Electro -magnetic Tomography) analysis of P300 showed reduced cortical current density distribution in the right frontal and bilateral temoral region in both schizoprenics and their siblings compared to controls. In the comparison of schizophrenics and siblings, although both group showed similar cortical current distribution, reduction of current density was notified in the left frontal pole region in schizophrenia compared to siblings. In addition f-NIRS (functional Near Infrared Spectroscopy) examination was undertaken in sibling of schizophrenia showing potential usefulness of f-NIRS to investigate biological substrate of schizophrenia.