RELTION BETWEEN PERIODONTAL STATUS AND CARDIOVASCULAR RISK FACTORS

高血压（HT）、高脂血症（HP）和吸烟习惯（SH）是心血管疾病（CVD）的主要危险因素。本研究的目的是调查牙周状态（PHS）与心血管疾病主要危险因素之间的关系。研究对象为在我校附属医院接受HT治疗的患者。检查了以下参数。CVD检查：年龄、性别、家族史、病史、吸烟史、生活方式、血压（SBP、DBP、MBP、PP）、脉波速度（PWV）、血液检查（TCH、HDL、LDL、TG、BUN、UA、Cr、FBS、HbA1c）、肥胖指数、用药情况。小PHS检查：探诊深度（PD）、探诊出血（BOP）、GI、菌斑指数、舌苔评分、呼吸气味。细菌检查：唾液、龈下菌斑。<结果>将患者分为HT高危组、HT合并HP高危组、HT合并SH高危组。HT合并SH高危组（n=32）与危险组（n=39） BOP （p<0.05）、GI （p<0.01）差异有统计学意义。提示可能与小灵通和心血管疾病有关。牙龈卟啉单胞菌（Pg），是假定的牙周病原体，不能在所有142个样本中培养。另一方面，实时PCR检测Pg的患病率为90%（10份样品中有9份）。PCR方法已用于检测无法培养的微生物，但这些方法与相关生物产生交叉反应。在未来，我们需要收集更多的数据来阐明该方法与PHS和CVD的相关性，以准确检测混合菌群中的菌种

Hypertension (HT), hyperlipidemia (HP) and smoking habit (SH) are major risk factors for cardiovascular disease (CVD). The purpose of this study is to investigate the association between periodontal status (PHS) and major risk factors for CVD. The subjects are patients who undergo treatment for a HT in an affiliated hospital of our university. The following parameters were examined. Examination of CVD : age, gender, family history, medical history, history of smoking, lifestyle, blood pressure (SBP,DBP,MBP,PP), pulse wave velocity (PWV), blood examination (TCH,HDL,LDL,TG,BUN,UA,Cr,FBS,HbA1c), obesity index, medications. Examination of PHS : probing depth (PD), bleeding on probing (BOP), GI, plaque index, coated tongue score, breath odor. Examination of bacteria : saliva, sub-gingival plaque.<Results>The subjects were divided into 2 groups : the risk group with a HT and the high-risk group with a HT and a HP or with a HT and a SH. There were significant differences in BOP (p<0.05) and GI (p<0.01) between high risk group with a HT and a SH (n=32) and the risk group (n=39). This suggested that there may be associated with PHS arid CVD. Porphyromoncis gingivalis (Pg), is putative periodontal pathogens, cannot becultivated in all of 142 samples. On the other hand, Pg prevalence detected by real time PCR was 90 % (9samples out of 10). PCR methods have been used for detection of microorganisms that cannot be cultivated but these methods have given cross-reactions with related organisms.In the future, we should collect more data to clarify correlation to PHS and CVD used by the method to accurately detect species in mixed bacteria populations