Study on patho-epidemiology of malignant lymphoma in Japan

这项研究基于大阪淋巴瘤研究组登记的恶性淋巴瘤病例和脓胸相关淋巴瘤(PAL)和鼻NK/T细胞淋巴瘤(NKTCL)病例。类风湿性关节炎发展成的恶性淋巴瘤也包括在内。对这些病例进行了流行病学和分子分析。从这些调查结果中获得的主要发现如下。1.在日本(5个研究所)、韩国(延世大学)和中国(中国医科大学)进行的病例对照研究表明，杀虫剂和化学溶剂是NKTCL(2006年国际癌症学会)的危险因素。PAL是一种与EBV相关的淋巴瘤。EBNA-2是EBV编码的潜伏基因之一，与PAL患者的预后相关(Int J癌症，2006)。淋巴增生性疾病(LPD)在类风湿关节炎(RA)患者中相对常见，其中甲氨蝶呤(MTX)被认为与RA的治疗有关。然后，我们比较了服用和不服用MTX的RA-LPD，显示它们之间没有根本的差异。(J Rheum 2007)。4.检测了来自淋巴细胞性白血病和淋巴瘤的50个细胞系中DNA错配修复基因ATM、ATR和MRE 11的突变。偶有发现ATM和MRE 11基因突变。这些突变可能导致基因组不稳定，最终导致淋巴样肿瘤。(癌症科学2006)。

The study based on the cases with malignant lymphomas registered in the Osaka Lymphoma Study Group and the cases with pyothorax-associated lymphoma (PAL) and nasal NK/T-cell lymphoma (NKTCL). Malignant lymphomas developed in rheumatoid arthritis were also included. Epidemiological and molecular analysis were performed on these cases. The main findings obtained from these findings were as follows.1. Case-control study in Japan(5 institutes), Korea (Yonsei Univ), and China (China Medical Univ) revealed that pesticides and chemical solvents were risk factors for development of NKTCL (Int J Cancer 2006).2. PAL is an EBV-associated lymphoma. Loss of EBNA-2 one of EBV-coded latent genes, correlated with prognosis of PAL patients (Int J Cancer 2006).3. It is known that lymphoproliferative disease (LPD) develop relative frequently in patients with rheumatoid arthritis (RA), in which methotrexate (MTX) administration for RA is supposed to be involved. Then we compared the RA-LPD with and without MT X medication, showing no fundamental differences between them. (J Rheum 2007).4.Mutations of DNA mismatch repair genes, ATM, ATR, and MRE 11, in 50 cell lines from lymphoid leukemias and lymphomas, were examined. Mutations of ATM and MRE 11 were occasionally found. These mutations might cause genome instability, and finally result in lymphoid neoplasias. (Cancer Sci 2006).