Development of a four-dimensional planning system and gated irradiation system for stereotactic body radiation therapy.

为建立立体定向体部放射治疗（stereotactic body radiation therapy，SBRT）的四维一体化照射系统，进行了以下研究：1.呼吸门控系统为扩大立体定向放射治疗对呼吸功能差患者的治疗范围，门控系统是理想的选择。本研究建立了流量门控信号发生器和压力门控信号发生器以及训练系统。2. SBRT的图像配准进行了CT、MRI和FDG（FLT）-PET之间的图像配准。该系统可用于靶区勾画和疗效评价。3. SBRTAs的临床应用已应用于180例SBRTAs患者。分别评价原发性肺癌和继发性肺癌的临床结果。4. JCOG 0403一项SBRT治疗I期肺癌的多机构II期研究正在进行中。

To establish an integrated four-dimensional irradiation system for SBRT (stereotactic body radiation therapy), the following research had been performed.1.Respiratory gating systemTo expand the stereotactic radiotherapy for a patient with poor respiratory function, a gating system is ideal. In this study, a flow and a pressure gated signal generators and a coaching system was established.2.Image registration for SBRTThe image registration between CT, MRI and FDG (FLT)-PET was performed. The system could be used for both target delineation and evaluation of response.3.Clinical application of SBRTAs many as 180 patients have been treated with this technique. The clinical results of primary lung cancer and secondary lung cancer was evaluated respectively.4.JCOG0403A mutli-institutional phase II study of SBRT for stage I lung cancer is ongoing.