Imaging of the morphology-function interaction of the brain and oral-maxillo-pharyngeal region

口颌咽区参与多种生理功能。本研究应用磁共振成像（MRI）、功能性MRI（fMRI）和基于体素的形态测量学（VBM）技术，探讨了脑和口颌咽区的形态和功能之间可能存在的相互作用。使用MRI电影进行两项语言功能研究。在这两项研究中，定制的电路连接到1.5T MRI设备，使外部触发脉冲控制扫描序列的定时，并提供同步的受试者的话语的听觉提示。受试者重复一个元音-辅音-元音音节（即，/阿帕/），并使用心脏电影的梯度回波序列测量运行。实验一：不同条件下唇、舌、软腭相互作用的线性和角度测量。[重复时间（TR）：120 ms、80 ms、60 ms、40 ms和30 ms]。同步移动 ...更多信息 对所有受试者的多个关节进行可视化和评估。不同的实验对象有不同的运动模式。在大的时间分辨率下观察到软腭的线性和角度测量的总体变化，而在咽闭合期间观察到小的时间分辨率下的微小变化。因此，MRI电影可用于口咽功能的评价。图像的质量和数据采集所需的时间根据参数而变化，例如，TR，应根据临床目的仔细确定。实验二：研究唇间距（IL）、第二颈椎至舌尖距离（TA）、第二颈椎至舌根距离（TP）和咽间角（Vp）的时间变化及其相关性。结果发现，IL、TA、TP和Vp在个体内水平上均表现出一定的时间变化，且与TR无关，均表现出显著相关性。在个体间水平上，IL与TA、IL与Vp呈显著相关。结果表明，嘴唇参与言语功能，舌尖和软腭之间存在密切的时间关系。此外，我们现在正在收集功能磁共振成像和VBM数据的主题与唇腭裂和不确定的关系，裂侧和激活的大脑皮层和小脑。少

Oral-maxillo-pharyngeal region is involved in many physiological functions. The present study was conducted in searching the possible interaction between morphology and function of the brain and oral-maxillo-pharyngeal region using magnetic resonance imaging (MRI) movie, functional MRI (fMRI) and voxel-based morphometry (VBM). Two studies were performed in speech function using MRI movie. In both studies, custom-made circuitry was connected to a 1.5T MRI apparatus to enable an external trigger pulse to control the timing of the scanning sequence and to provide an auditory cue for synchronization of the subject's utterance. The subject repeated a vowel-consonant-vowel syllable (i.e., /apa/) in whispers, and the run was measured using a gradient echo sequence for a cardiac cine. Experiment 1 : Linear and angular measurements for the interaction among the lips, tongue and soft palate with different conditions. [repetition time (TR) : 120ms, 80ms, 60ms, 40ms and 30ms]. The simultaneous mov … More ement of multiple articulators was visualized and assessed in all subjects. There were individualized patterns of movement across subjects. Gross changes in linear and angular measurements of the soft palate were observed with large time resolutions, while minute changes were observed with small time resolutions during velopharyngeal closure. It was thus concluded that MRI movie might be useful in the evaluation of oropharyngeal function. The quality of the image and the time required for data acquisition vary according to the parameters, e.g., TR, which should be carefully determined according to the clinical objectives. Experiment 2 : Temporal changes and correlations were studied for the inter-lip distance (IL), distance between the second cervical vertebra and the tip of the tongue (TA), distance between the second cervical vertebra and the base of the tongue (TP) and the velopharyngeal angle (Vp). It was found that the IL, TA, TP and Vp showed given temporal changes in the intra-individual level, and showed significant correlations irrespective of TR. In the inter-individual level, the Il and TA, and the IL and Vp showed significant correlations. It was suggested that the lips are involved in speech function with intimate temporal relationship between the tip of the tongue and soft palate. Furthermore, we are now collecting fMRI and VBM data in subjects with and without cleft lip and palate to determine the relationship between the cleft side and activation of the cerebral cortex and cerebellum. Less