The effects of alcohol and cigarette consumption on blood pressure and the renal function in middle-aged healthy Japanese men

中年男性吸烟者血清肌酐浓度较低。吸烟可显著影响循环系统，引起肾小球滤过率（GFR）增加，从而降低血清肌酐。GFR升高与全身血压（BP）升高之间存在显著的线性相关性，仅在吸烟者中观察到，而在非吸烟者中没有。吸烟者GFR的增加被认为与他们空腹血清胰岛素水平的增加部分相关。GFR和BP升高是中年男性尿白蛋白排泄增加的主要因素，提示吸烟可能由于GFR和BP升高而导致肾脏恶化。

The levels of serum creatinine concentration are lower in middle-aged male smokers. Cigarette smoking may significantly affect the circulatory system, causing increases in glomerular filtration rate (GFR) and thus decreases in serum creatinine. A significant linear correlation between the increases in GFR and those in systemic blood pressure (BP) was observed only in smokers, but not in nonsmokers.The increases in GFR in smokers were suggested to be partly related to their increased fasting serum insulin levels. The high GFR and BP were shown to be the major factors related to increased urinary excretion of albumin in middle-aged male population, suggesting that smoking may cause the renal deterioration due to the elevated GFR and BP.