New Methods for Structural Biology in Solution

新技术将被开发出来，这些技术将足够快速和廉价，以与生物学家通常进行的诱变实验竞争和取代诱变实验，以识别和表征蛋白质的重要功能部分。结合各种选择性标记方案的核磁共振（NMR）波谱技术将以更高的速率和更高的准确性开发蛋白质-配体相互作用的鉴定和结构表征。此外，蛋白质的三维结构和具有重要生物学功能和未知折叠的蛋白质结构域将通过核磁共振确定。该项目的目标是对制药业有直接影响的技术。

New technologies will be developed that are sufficiently rapid and inexpensive to compete with and replace the mutagenesis experiments that biologists usually perform to identify and characterize the functionally important parts of a protein. Nuclear magnetic resonance (NMR) spectroscopy techniques in combination with various selective labelling schemes will be developed with the goal of identification and structural characterization of protein-ligand interactions at increased rates and enhanced accuracy. In addition, the three-dimensional structures of proteins and protein domains of biologically important functions and unknown fold will be determined by NMR. The project aims at techniques of direct impact in pharmaceutical industry.