regulatory mechanisms underlying proliferation, differentiation, migration and integration in transplanted retinal stem cells in diseased retinas

视网膜再生疗法的发展及其对严重视力障碍患者恢复视功能的努力最近引起了人们的极大关注。我们对疾病视网膜中移植的祖细胞的增殖、分化、迁移和整合的调控机制的了解还远远不能令人满意。我们介绍了我们的实验，并概述了细胞治疗视网膜损伤和疾病的希望和问题。我们的经验之一是有效地利用稳定的细胞增殖来准备足够数量的干细胞库来建立干细胞疗法。WNT信号可能为使用从睫状缘制备的成年视网膜前体细胞进行干细胞治疗提供一种新的策略。此外，将祖细胞移植到受损的视网膜表明，宿主视网膜的条件通过gp130信号通路影响移植细胞的命运。因此，控制宿主微环境可能会支持将移植的祖细胞适当分化到视网膜进行再生治疗。

The development of retinal regenerative therapy and its efforts to restore visual function in patients with significant visual impairment has recently drawn much attention. Our knowledge of regulatory mechanisms underlying proliferation, differentiation, migration and integration in transplanted progenitors in diseased retinas is far from satisfactory. We introduce our experiments and outline the hopes and problems of cell therapy for damaged and diseased retinas. One of our experiences effectively utilizes stable cell proliferation to prepare a sufficient amount of stem cell pool to establish a stem cell therapy.Wnt signaling may provide a novel strategy for stem cell therapy using adult retinal progenitors prepared from the ciliary margin. Furthermore, transplantation of progenitor cells into the damaged retina revealed that conditions in the host retina affect the fate of transplanted cells through the gp130-signaling pathway. Manipulating host microenvironments may therefore support the proper differentiation of transplanted progenitor cells into the retina for regenerative therapy.