Improved biosecurity through the engineering of microbial ecosystems

该项目旨在提供数据和理解，帮助开发耐药细菌分布变化的预测模型，以及关键生物安全威胁的监测和响应计划。微生物，包括共生体和病原体，可以生活在包括动物宿主在内的一系列环境中的复杂群落中。现在已经知道，这些群落(称为微生物群)可以对动物健康产生深远的影响。该项目旨在了解抗菌素耐药基因在猪肠道微生物群中的位置以及它们如何在这个复杂的微生物群落成员之间移动，并提供有关益生菌如何用于减少对抗生素的依赖的信息。

This project aims to provide data and understanding that will help develop predictive models for changes in the distribution of drug-resistant bacteria, and surveillance and response programs for key biosecurity threats. Microorganisms, including commensals and pathogens, can live in complex communities in a range of environments including animal hosts. It is now known that these communities (known as microbiomes) can exert a profound effect on animal health. This project seeks to understand where antimicrobial resistance genes reside in pig gut microbiotia and how they move between members of this complex microbial community, and to provide information on how probiotics may be used to reduce dependence on antibiotics.