Study of therapeutic effects of vessel-permeable 11R protein on stroke

我们利用基因重组技术制备了11 R与超氧化物歧化酶、TGF-β、低密度脂蛋白受体、内皮型一氧化氮合酶和超氧化物歧化酶的融合蛋白。内皮型NOS-11 R向脑血管内传导，使脑血管扩张。（中风。38：1354-61，2007）。11 R蛋白可穿透动脉血管各层，即使是大分子量的蛋白也可穿透11 R蛋白所携带的血管各层。脑实质内未见~（11）R信号。

We made fusion proteins of 11R with superoxide-dismutase, TGF-beta、low-density lipoprotein receptor, endothelial NOS, and superoxide-dismutase by using genetic recombination technique. endothelial NOS-11R transmitted into the brain blood vessels, and it made these vessels dilated, successfully. (Stroke. 38 : 1354-61, 2007). We also revealed that 11R protein could transmit into any layers of arterial vessels, and even large molecular weight proteins could penetrate into the any layers of the vessels with 11R protein. Meanwhile, we observed no signals of 11R in the brain parenchyma.