The Origins of Chirality and Amplification in Asymmetric Autocatalysis

生物相关的化合物如l -氨基酸是由其中一种对映体组成的。这种现象被称为生物同手性，同手性的起源引起了广泛的兴趣。不对称自催化，即Soai反应，是手性产物作为手性催化剂进行自身生产的反应。研究发现，碳、氢、氧的手性同位素体、自发的绝对不对称合成、核酸碱等非手性有机化合物形成的手性晶体是不对称自催化的手性引发剂。高对映体富集的手性化合物具有与手性引发剂相对应的绝对构型。

Biologically related compounds such as L-amino acids are composed of one of the enantiomers. The phenomenon is called biological homochirality, and the origin of homochirality has attracted broad interest. Asymmetric autocatalysis, i.e., Soai reaction, is a reaction in which chiral product acts as a chiral catalyst for its own production. It was found that chiral isotopomers of carbon, hydrogen and oxygen, spontaneous absolute asymmetric synthesis, chiral crystals formed from achiral organic compounds such as nucleic acid base act as chiral initiators of asymmetric autocatalysis. Highly enantioenriched chiral compounds withthe corresponding absolute configurations with those of chiral initiators are obtained.