Cross-Coupling through Selective Cleavage of C-H and C-C Bonds

在钯或铑催化剂的存在下，适当功能化的芳香族和杂芳香族底物与芳基卤化物、烯烃和炔的偶联反应有效地进行。特别是芳香族羧酸，通过C-H和C-C键的裂解进行多重偶联，形成了结构上有趣的偶联化合物。此外，还开发了一些以铜和镍为催化剂的芳香族化合物C-H转化反应。

The coupling reaction of suitably functionalized aromatic and heteroaromatic substrates with aryl halides, alkenes, and alkynes proceeded effectively in the presence of a palladium or rhodium catalyst. Especially, aromatic carboxylic acids was found to undergo multi-coupling via C-H and C-C bond cleavages to afford structurally interesting pi-conjugated compounds. Furthermore, a number of C-H transformation reactions of aromatic compounds by using copper and nickel catalysts have been developed.