Growth factor and extracellular matrix in neural reconstruction

神经元损伤后几乎不会出现轴突再生/萌发，主要是由于抑制因子的诱导。硫酸软骨素是最广为人知的抑制因子之一。我们发现，硫酸角蛋白抑制轴突再生/发芽，其抑制活性与硫酸软骨素一样强。为了抑制作用，蛋白多糖的所有成分(即硫酸角蛋白、硫酸软骨素、核心蛋白)都是必需的。我们的数据表明，核心蛋白对硫酸角蛋白和硫酸软骨素的适当呈现是重要的，这些糖链可能由神经元上的受体(S)读取。

Axonal regeneration/sprouting hardly occur after neuronal injuries, mainly due to induction of inhibitory factors. Chondroitin sulfate is one of most well-known inhibitory factors. We found that keratan sulfate inhibits axonal regeneration/sprouting, and its inhibitory activity is as strong as that of chondroitin sulfate. For the inhibition, all the components of proteoglycans(i. e., keratan sulfate, chondroitin sulfate, core protein) are required. Our data suggest that an appropriate presentation of keratan sulfate and chondroitin sulfate by the core protein is important, and these sugar chains may be read by receptor(s) on neurons.