Enhancement of bone healing during distraction osteogenesis

采用兔胫骨延长术，观察局部灌注生长因子和双磷酸盐对延长段的影响。当FGF-2和双磷酸盐在巩固期同时输注时，骨愈合显著增强。FGF-2刺激骨形成，而双膦酸盐抑制骨吸收。我们相信这种方法是有效的，以缩短治疗时间的肢体延长，并适用于在临床领域作为一种新的药物输送系统。

Rabbit tibial lengthening was achieved to examine the effect of local infusion of the growth factors and bisphosphonate into the lengthened segment. When FGF-2 and bisphosphonate were infused simultaneously during consolidation phase, bone healing was dramatically enhanced. FGF-2 stimulated bone formation while bisphosphonate inhibited bone resorption. We believe this method is valid to shorten the treatment time of limb lengthening and is applicable in the clinical field as a new drug delivery system.