Age-dependant NO production and its regulation involved in the uterus and placenta of pregnant rat

研究了妊娠大鼠子宫内膜和胎盘中一氧化氮的产生及其调控。妊娠第17.5天子宫内膜和胎盘NO生成水平分别达到峰值（GD17.5）和GD15.5。这些一氧化氮的产生主要来源于组织中诱导的一氧化氮合酶。NO产生抑制剂在GD17.5时通过子宫内膜典型的凋亡信号引起细胞凋亡，提示子宫内膜NO峰值对细胞存活和维持子宫形成至关重要。

NO production and its regulation involved in the uterine endometrium and placenta were examined in pregnant rat. NO productions level peak on gestational day 17.5 (GD17.5)and GD15.5 in the endometrium and placenta, respectively. These NO productions were mainly derived from induced NO synthase in the tissues. Inhibitor of NO production caused apoptosis through typical apoptotic signals in the endometriumu on GD17.5, suggesting that an NO peak in the endometrium is essential to cell survival and the maintenance of uterine formation.