Immunohistochemical studies of water channel, aquaporins, in the brain.

详细的免疫组织化学定位的水通道，水通道蛋白，在大脑中进行了检查，以了解水在脑组织中的转移。除了以往的研究描述水通道蛋白-4局限于星形胶质细胞的血管周围细胞膜外，我发现水通道蛋白-4广泛分布于星形胶质细胞的质膜上。这一结果表明水通道蛋白-4在大脑的水处理中起着非常重要的作用。此外，还检测了水通道蛋白在小鼠组织中的分布。我发现水通道蛋白-5在小鼠呼吸道上皮中的分布比在大鼠呼吸道上皮中的分布更广泛。小鼠呼吸上皮中的水通道蛋白-5似乎在维持呼吸功能中起重要作用。

Detailed immunohistochemical localization of water channel, aquaporins, in the brain was examined to understand water transfer in the brain tissue. In addition to the previous studies which described that aquaporin-4 was restricted to the perivascular cell membrane of astrocytes, I revealed that aquaporin-4 was widely distributed on the plasma membrane of astrocytes. This result suggests that aquaporin-4 plays very important role in water handling in the brain. In addition, distribution of aquaporins was examined in the mouse tissue. I found that aquaporin-5 is more widely distributed in the mouse respiratory epithelium than that in the rat. Aquaporin-5 in the mouse respiratory epithelium seems to play an important role in maintaining the respiratory function.