Functional analysis of a new Trem molecule

骨髓细胞上表达的触发受体（Trem）家族调节免疫细胞的激活状态。在这项研究中，我们试图揭示一个新发现的Trem分子的功能。据报道，当细胞被激活时，其他Trem成员的表达水平上调或下调。然而，该分子在树突状细胞（DCs）上的表达在激活后没有改变。此外，对基因敲除小鼠的分析结果表明，该分子不参与dc对凋亡细胞的摄取。另一方面，基因敲除小鼠在细胞因子产生和抗体诱导关节炎方面的反应略有增强，表明该分子可能负向参与炎症反应。

Triggering receptor expressed on myeloid cells (Trem) family is known to regulate activation status of immune cells. In this study, we tried to uncover the function of a newly identified Trem molecule. It has been reported that the expression levels of other Trem members are up-regulated or down-regulated when the cells were activated. However, the expression of this molecule on dendritic cells (DCs) was not altered after their activation. In addition, the results from analyses of gene-knocked out mice suggest that this molecule is not involved in uptake of apoptotic cells by DCs. On the other hand, gene knocked-out mice showed slightly enhanced responses in terms of cytokine productions and antibody induced arthritis, suggesting that this molecule may be negatively involved in inflammatory responses.