Cytoskeletal rearrangement of neutrophils after one-lung ventilation

单肺通气(OLV)后的再扩张会导致中性粒细胞重新聚集到肺内，并导致肺泡损伤。与OLV相关的中性粒细胞的形态和功能行为尚未完全阐明。我们的研究表明，OLV后的肺再扩张诱导循环中中性粒细胞的细胞骨架重排，并促进其毛细血管的隔离和迁移，特别是在通气性肺中。西维来司他阻断中性粒细胞弹性蛋白酶可抑制这些事件并改善肺氧合。

Re-expansion following one-lung ventilation (OLV) leads to neutrophil recruitment into the lung and causes alveolar damage. The morphological and functional behaviors of neutrophils that are associated with OLV have not been thoroughly elucidated. Our study shows that lung re-expansion following OLV induces cytoskeletal rearrangements in circulating neutrophils and promotes their capillary sequestration and migration, particularly in the ventilated lung. Blockade of neutrophil elastase by sivelestat inhibits these events and improves pulmonary oxygenation.