Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction

为了鉴定肿瘤相关靶基因，建立食管鳞状细胞癌的分子靶向治疗，我们整合了肿瘤基因组/表观基因组改变的详细信息，肿瘤细胞对候选靶基因的功能依赖（癌基因依赖），以及这些基因表达状态改变的临床病理意义。使用这种方法，我们成功地鉴定了一些可能的新的癌基因和肿瘤抑制基因，这些基因可能是食管癌的有用治疗和诊断靶点。

In order to identify target tumor-related genes for establishing molecular targeting therapy in patients with esophageal squamous-cell carcinoma, we integrated detailed information of genomic/epigenomic alterations in tumors, functional addiction of tumor cells to candidate target genes (oncogene addiction), and clinicopathological significance of altered expression status of those genes. Using this approach, we successfully identified a number of possible novel onocogene and tumor suppressor genes, which may be useful therapeutic as well as diagnostic targets for esophageal cancers.