Identification of functional fimbria domain of periodontopathogen for the clinical application

牙龈卟啉单胞菌是一种牙周病原体，可通过内吞途径进入宿主牙周细胞，参与疾病的进展。本研究旨在从菌基蛋白毒力和细菌胞内定位两方面探讨牙周病慢性发病的机制。牙龈假单胞菌受牙龈上皮细胞侵袭，并向细胞外扩散。本研究提示牙龈卟啉卟啉从牙龈上皮细胞中退出是由Rabll、RalA和胞囊复合体介导的。这也表明牙龈假单胞菌可以避免先天免疫反应，从而导致牙周病的慢性情况。

Porpnyromonas gingivalis, a periodontal pathogen, can enter host periodontal cells via endocytic pathway, which is involved in the disease progression. The present study was performed to elucidate the mechanism of the chronic situation of periodontal diseases in terms of the virulence of fimbrillin and of the bacterial intracellular localization. P.gingivalis was invaded by gingival epithelial cells and exited to extracelluolar milieu. This study suggests that the exit of P.gingivalis from gingival epithelial cells is mediated by Rabll, RalA, and exocyst complex. It also suggests that P.gingivalis can avoide the innate immune response, which can lead to the chronic situation of periodontal diseases.