The effects of food intake restriction that is not in coordination with circadian rhythms on reproductive functions in young women

基于青春期女性的饮食习惯会影响育龄期女性的生活质量这一新概念，本研究采用问卷调查的方法，对育龄期女性的日常饮食习惯、对身高的自我认知、18- 19岁女大学生节食实践及一般情况调查20岁，以引出影响生殖功能的显著饮食习惯因素。此外，我们通过食物营养分析更精确地检查了饮食习惯。此外，我们还通过青年雌性大鼠实验，研究了食物摄入限制时间与动情周期的关系，以了解饮食习惯对生殖功能的影响，问卷调查证实了不吃早餐是影响青年女性生殖功能的重要因素之一，并显示了夜间生活方式与不吃早餐有关的可能性。食物营养分析显示，不吃早餐的学生没有补充食物能量，提示早餐是热量摄入不足的原因之一。此外，动物实验表明，白天饥饿对年轻雌性大鼠的发情周期有更大的损害。例如，根据这些结果，我们提出了一个新的假设，即日常生活中的食物消耗时间是影响年轻人生殖功能的重要问题。这些发现将有助于建立一个新的饮食教育计划，以减少饮食对年轻女性生殖功能的不利影响。

On the basis of the novel concept that diet habits in young women during the adolescence influence the subsequent quality of life(QOL) of women of the reproductive ages, in this study, we conducted the questionnaire survey concerning the daily dietary habits, the self-recognition of body stature, dieting practice and general conditions from female college students of 18-20 years old in order to elicit significant dietary habit factors that affect reproductive functions. In addition, we examined dietary habits more precisely by food nutritional analysis. Furthermore, using young adult female rat experiments, we investigated the relationship between the timing of food intake restriction and estrous cycle to know the effects of dietary habits on the reproductive functions.The questionnaire survey confirmed that breakfast skipping is one of the important factors that adversely affect reproductive functions in young women and showed the possibility that nocturnal life style is associated with breakfast skipping. Food nutritional analysis showed that students with breakfast skipping did not supplement themselves with food energy, suggesting that breakfast is one of the reasons for lack of calories take in. In addition, animal experiments showed that greater impairment of the estrus cycle in young female rats that were starved during the day, i. e., the daytime(non-active phase) than those that were starved at night(active phase).From these results, we proposed a new hypothesis that the timing of food consumption in daily life is an important issue that affects reproductive function in the young. These findings will contribute to establishing a new dietary education program to reduce the adverse effects of diets on reproductive functions in young women.