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Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites

Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites
利用癌症化学预防微生物代谢物发现细胞分裂调节因子
批准号:
21580132
负责人:
IIDA Akira
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
翻译
通过对不同菌株的筛选和培养条件的优化,获得了足量的倍半萜类化合物TTC-A,该化合物是粉红单端孢菌(Trichothecium roseum)的代谢产物,同时具有抗肿瘤和促肿瘤作用。已知TTC-A是多核Raji细胞的诱导剂。这可能与ras基因和细胞分化相关的信号转导调节细胞周期有关。
英文摘要
Sufficient quantities of sesquiterpene TTC-A, which is a metabolite of Trichothecium roseum showing anti-tumor promoting and tumor promoting effects simultaneously, were obtained by selecting various strains and modifying cultural conditions. TTC-A is known to be an inducer of multinucleated Raji cells. This was deduced to result from modulation of cell cycles regulated by signal transductions associated with ras gene and cell differentiation.
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会议论文
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [田島知子, 川井悟, 常盤野哲生, 中澤伸重, 吉澤結子, 飯田彰]
通讯作者: 飯田彰
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [徳田春邦, 鈴木章司、金澤由佳、飯田彰]
通讯作者: 鈴木章司、金澤由佳、飯田彰
Design and synthesis of DNA topoisomerase II inhibitors targeting the proton-transfer process
  • 批准号:
    12470476
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $3.01万
  • 财政年份:
    2000
  • 负责人:
    IIDA Akira
  • 依托单位:
Study for the action and side effects of anesthetics using plasma membrane Ca-ATPase as a model
  • 批准号:
    12671919
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.18万
  • 财政年份:
    2000
  • 负责人:
    IIDA Akira
  • 依托单位:
Asymmetric total synthesis of a novel tumor promoter
  • 批准号:
    10672087
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.86万
  • 财政年份:
    1998
  • 负责人:
    IIDA Akira
  • 依托单位:
Design, structures and functions of stabilized artificial ion channels
  • 批准号:
    07680629
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.28万
  • 财政年份:
    1995
  • 负责人:
    IIDA Akira
  • 依托单位:
海外基金