Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites
Discovery of cell division regulating factors using cancer chemopreventive microbial metabolites
批准号:
21580132
负责人:
IIDA Akira
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
通过对不同菌株的筛选和培养条件的优化,获得了足量的倍半萜类化合物TTC-A,该化合物是粉红单端孢菌(Trichothecium roseum)的代谢产物,同时具有抗肿瘤和促肿瘤作用。已知TTC-A是多核Raji细胞的诱导剂。这可能与ras基因和细胞分化相关的信号转导调节细胞周期有关。
英文摘要
Sufficient quantities of sesquiterpene TTC-A, which is a metabolite of Trichothecium roseum showing anti-tumor promoting and tumor promoting effects simultaneously, were obtained by selecting various strains and modifying cultural conditions. TTC-A is known to be an inducer of multinucleated Raji cells. This was deduced to result from modulation of cell cycles regulated by signal transductions associated with ras gene and cell differentiation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
カビ由来の発がんプロモーター
真菌致癌启动子
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[田島知子, 川井悟, 常盤野哲生, 中澤伸重, 吉澤結子, 飯田彰]
通讯作者:
飯田彰
不完全菌Trichothecium roseum代謝産物の抗発がんプロモーター作用
玫瑰色单孢霉代谢物的抗癌启动子活性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[徳田春邦, 鈴木章司、金澤由佳、飯田彰]
通讯作者:
鈴木章司、金澤由佳、飯田彰
Design and synthesis of DNA topoisomerase II inhibitors targeting the proton-transfer process
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批准号:12470476
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.01万
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财政年份:2000
-
负责人:IIDA Akira
-
依托单位:
Study for the action and side effects of anesthetics using plasma membrane Ca-ATPase as a model
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批准号:12671919
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2000
-
负责人:IIDA Akira
-
依托单位:
Asymmetric total synthesis of a novel tumor promoter
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批准号:10672087
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1998
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负责人:IIDA Akira
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依托单位:
Design, structures and functions of stabilized artificial ion channels
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批准号:07680629
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1995
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负责人:IIDA Akira
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依托单位:
海外基金