Analysis on mechanism of development of sensitization which decides symptom onset of allergic disease

为了批准抗原致敏或成为过敏性疾病，可能需要有抗原在体内不存在的时期。提示与连续接触相比，间歇接触抗原可引起过敏反应。原因之一是在抗原撤除期，来自抗原呈递细胞的IL-12细胞因子产生减少。这一事实有可能提高过敏性疾病的预防或治疗效果。

To approve the antigen sensitization or to become an allergic condition, it might be required to have the period when the antigen did not exist in the body. It is suggested that the hypersensitivity responses are caused by intermittent exposure of antigen when compared with continuous exposure. One of the reasons is that the IL-12 cytokine production from the antigen-presenting cell decreases at antigen withdrawal period. This fact has the possibility to improve the preventing or therapeutic efficacy of allergic diseases.