Effects of placental transfer of phytoestrogen on physiological function in mammals

库美司醇可降低妊娠小鼠肠内ALP活性，增加泌乳小鼠乳腺内iga分泌细胞数量。母鼠妊娠和哺乳期给药库美孕酮可通过母奶影响新生小鼠肾脏钙代谢，尤其是雄性新生小鼠。植物雌激素可通过雌激素受体作为雌激素激动剂和拮抗剂。

Coumestrol administration decreases the ALP activity in intestine of pregnant mice and increases the numbers of IgA-secreting cells in mammary gland of lactating mice. Coumestrol administration to maternal mice during pregnancy and lactation affects renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk. Phytoestrogens may act as both estrogen agonists and antagonists through estrogen receptor.