Development of Chemoenzymatic Methods for the Selective Elaboration of Polyfunctionalised Therapeutic Agents to Oligomers with Improved Efficacy

该项目的目的是筛选一种新的基因工程酶，以选择性地操纵已证实的治疗剂，从而最终获得更有效的药剂/药物的聚合衍生物。酶库和化学操作的组合使用，以产生更强大的聚合物变体已经建立的药物从来没有在澳大利亚进行过。这一方法有能力产生迄今无法获得的各类治疗实体，并为该国的生物技术工业提供一个新的和独特的技术平台。

The aims of the project are to screen a novel collection of genetically engineered enzymes for their capacity to selectively manipulate proven therapeutic agents so that, ultimately, much more potent polymeric derivatives of the agent/drug can be obtained. The combined use of enzyme libraries and chemical manipulations to generate more powerful polymeric variants of already established drugs has never been undertaken previously in Australia. This approach has the capacity to generate hitherto inaccessible classes of therapeutic entities and to provide a new and unique technology platform for the country's biotechnology industry.