Relationship between leptin and orofacial development in fetus.

与本研究相关的前期研究结果表明，瘦素也作用于味觉器官。我们发现味觉器官也是瘦素的作用部位。本实验结果不能证实瘦素受体在胎鼠下颌骨中的表达。如果胎儿下颚没有瘦素受体的表达，则瘦素对下颚发育直接作用的可能性较低。然而，瘦素参与口面部发育的中枢系统的可能性，是未来研究的主题。

From previous research results related to this study clarified that leptin also acts on taste organ. We found that taste organ is also the site of action of leptin. The results of this experiment could not confirm the expression of leptin receptor in fetal mouse mandible. If no expression of leptin receptor in the jaw of a fetus, the possibility of direct action of leptin to the jaw development is considered to be low. However, the possibility that leptin is involved in the orofacial development mediated the central system, is a subject of future investigation.