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Development of basic technologies for new in vivo imaging to promote life science research

Development of basic technologies for new in vivo imaging to promote life science research
开发新型体​​内成像基础技术,推动生命科学研究
批准号:
21220009
负责人:
TAKAHASHI Satoru
金额:
$119.97万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009-05-11 至 2014-03-31

项目摘要

项目成果

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中文摘要
翻译
在本申请中,使用各种荧光标记的蛋白质和尚未实际使用的基因工程策略,我们试图开发新的体内成像方法。电生理学和组织学分析最常用于神经科学研究。然而,使用新的荧光标记技术,我们开发了一种监测神经元活动历史的系统,迄今为止,使用基因操纵小鼠还不可行。
英文摘要
In this application, using a variety of florescence-labeled proteins and genetic engineering strategies that have not been practically used, we attempted to develop new in vivo imaging methods. Electrophysiological and histological analyses most often have been used for studies in neuroscience. However, using a new fluorescence labeling technology, we developed a system to monitor history of neuronal activity, which has not been feasible to date by using gene-manipulated mice.
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会议论文
解剖学・発生学研究室
解剖/胚胎学实验室
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1002/dvg.22031
发表时间: 2012-07-01
期刊: GENESIS
影响因子: 1.5
作者: [Matsumoto, Ken, Azami, Takuya, Ema, Masatsugu]
通讯作者: Ema, Masatsugu
DOI: 10.1038/ncomms4147
发表时间: 2014-01-01
期刊: NATURE COMMUNICATIONS
影响因子: 16.6
作者: [Hamada, Michito, Nakamura, Megumi, Takahashi, Satoru]
通讯作者: Takahashi, Satoru
DOI: 10.1538/expanim.63.183
发表时间: 2014
期刊: Experimental animals
影响因子: 2.4
作者: [Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K]
通讯作者: Yagami K
共 27 条
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