Cell transformation route and the developmental mechanics which assumed chromosomal aneuploidy an origin

人们一直认为，辐射致癌的第一个目标是DNA。然而，这还没有被证明是辐射致癌的。我们发现非整倍体细胞的频率与辐射诱导细胞转化的频率密切相关，但基因突变不相关。非整倍体在细胞转化早期出现频率较高。这些结果强烈提示低剂量辐射致癌的主要靶点不是DNA，而是中心体，中心体是构成染色体稳态维持机制的蛋白质。

It has been believed that the first target of radiation carcinogenesis is DNA. However, this is not proved for radiation carcinogenesis yet. We discovered that frequency of aneuploid cell was closely related to that of radiation-induced cell transformation, but gene mutation was not. Aneuploidy was seen in high frequency in early process of cell transformation. These results strongly suggest that a main target of carcinogenesis by low dose radiation is not DNA, but is centrosome, which are the proteins to constitute chromosomal homeostasis maintenance mechanism.